WebThe most important regulator of DC migration is the chemokine receptor CCR7. Consistent with this, CCR7-deficient DCs show a 90 percent reduction in migration from the periphery in response to inflammatory stimuli (10, 36).An elegant intravital microscopy study demonstrated that CCR7 is required for the LPS-induced directed migration of DCs toward … Web4. sep 2024 · Toll-like receptor (TLR)-7 is an endosomal innate immune sensor capable of detecting single-stranded ribonucleic acid. TLR7-mediated induction of type I interferon and other inflammatory cytokine production is important in antiviral immune responses. Furthermore, altered TLR7 expression levels are implicated in various autoimmune …
Mechanisms maintaining peripheral tolerance Nature …
WebScience Immunology—publishing critical advances in all areas of immunological research, including new tools and techniques. ... OXPHOS promotes apoptotic resistance and cellular persistence in T H 17 cells in the periphery and tumor … Web5. okt 2024 · In the periphery, autoreactive T cells that have escaped negative selection in the thymus subsequently become activated by interaction with corresponding self … emily hardt
The Role of Autoimmune Regulator (AIRE) in Peripheral Tolerance - Hindawi
WebIt has been clear for some time that immune cells capable of recognizing self-proteins exist in normal individuals without seemingly causing harm. The 'peripheral tolerance' mechanisms that keep these cells in check are the focus of intense research, not least because defects in these pathways might… View on Nature ncbi.nlm.nih.gov Save to Library Web1. aug 2005 · The migration of dendritic cells (DCs) to lymph nodes from the periphery supports the onset of immune responses. Whereas several molecules that are required for DCs to leave the periphery have... Web17. dec 2009 · In the periphery, autoreactive T cells chronically engaged by self pMHC complexes die by apoptosis as a result of a combination of molecular events: Fas receptor engagement by FasL and... emily harding nz