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Gata-3 breast cancer

WebJan 24, 2024 · 1. Introduction. GATA binding protein-3 (GATA3) is a transcription factor that regulates cell differentiation and is thought to be a sensitive biomarker for carcinomas of breast and urothelial origins [1].However, GATA3 expression is not specific to these sites and can be seen in other normal and neoplastic tissues, including tumors originating … WebJul 1, 2012 · GATA3 (GATA binding protein 3 to DNA sequence [A/T]GATA[A/G]) is 1 of 6 members of a zinc finger transcription factor family, and it plays an important role in promoting and directing cell proliferation, development, and differentiation in many tissues and cell types, 1, 2 including luminal glandular epithelial cells of the mammary gland, 3–5 …

Role of GATA3, CK7, CK20 and CK14 in distinguishing urinary ... - LWW

WebOct 3, 2024 · Huo L, Gong Y, Guo M, Gilcrease MZ, Wu Y, Zhang H, et al. GATA-binding protein 3 enhances the utility of gross cystic disease fluid protein-15 and mammaglobin A in triple-negative breast cancer by ... WebWe associated GATA3 expression with patient outcomes and clinicopathologic variables. Expression of GATA3 was significantly increased in breast cancer, in situ lesions, and … aterm pa-wg2600hs2マニュアル https://heavenearthproductions.com

GATA3 somatic mutations are associated with …

• Naylor MJ, Ormandy CJ (2007). "Gata-3 and mammary cell fate". Breast Cancer Research. 9 (2): 302. doi:10.1186/bcr1661. PMC 1868924. PMID 17381824. • Ho IC, Vorhees P, Marin N, Oakley BK, Tsai SF, Orkin SH, Leiden JM (May 1991). "Human GATA-3: a lineage-restricted transcription factor that regulates the expression of the T cell receptor alpha gene". The EMBO Journal. 10 (5): 1187–92. doi:10.1002/j.1460-2075.1991.tb08059.x. PMC 452772. PMID • Naylor MJ, Ormandy CJ (2007). "Gata-3 and mammary cell fate". Breast Cancer Research. 9 (2): 302. doi:10.1186/bcr1661. PMC 1868924. PMID 17381824. • Ho IC, Vorhees P, Marin N, Oakley BK, Tsai SF, Orkin SH, Leiden JM (May 1991). "Human GATA-3: a lineage-restricted transcription factor that regulates the expression of the T cell receptor alpha gene". The EMBO Journal. 10 (5): 1187–92. doi:10.1002/j.1460-2075.1991.tb08059.x. PMC 452772. PMID 1827068. WebThe transcription factor T-bet is a negative regulator of GATA-3 in the immune system. In this study, we report that insulin increases the expression of T-bet in breast cancer cells, which correlates with reduced expression of GATA-3, FOXA1, and the ERalpha:FOXA1:GATA-3 target gene GREB-1. WebDec 15, 2005 · GATA binding protein 3 (GATA3), a transcriptional activator, emerged as one of the top genes with low expression in the meta-signature. In breast cancer, high … aterm pa-wg2600hp3

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Gata-3 breast cancer

Higher levels of GATA3 predict better survival in women with …

WebAug 6, 2024 · All breast cancers and pre-cancers, with the exception of lobular carcinoma in situ (LCIS), should be tested for these hormone receptors when they have the breast biopsy or surgery. Results for ER and PR are reported separately and can be reported in different ways: Negative, weakly positive, positive. WebGATA3 can be particularly useful as a marker for metastatic breast carcinoma, especially triple-negative and metaplastic carcinomas, which lack specific markers of mammary origin. Finally, GATA3 labeling may help distinguish metaplastic carcinoma from malignant … National Center for Biotechnology Information

Gata-3 breast cancer

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WebJun 1, 2009 · GATA-3 expression in breast cancer has a strong association with estrogen receptor but lacks independent prognostic value. Cancer Epidemiol Biomarkers Prev 17 … WebJun 23, 2009 · The expression of additional genes, other than oestrogen receptor (ER), may be important to the hormone-responsive phenotype of breast cancer. Microarray analyses have revealed that forkhead box A1 (FOXA1) and GATA binding protein 3 (GATA-3) are expressed in close association with ERα, both encoding for transcription factors with a …

WebJan 18, 2024 · GATA3 somatic mutations are associated with clinicopathological features and expression profile in TCGA breast cancer patients Introduction. Breast … WebFeb 1, 2016 · 1. Introduction. GATA3 is 1 of 6 members of the GATA family of transcription factors, whose members contain zinc-finger DNA binding domains that bind to consensus 5′- (A/T) GATA (A/G)-3′ motifs [1], [2]. The family members, GATA1-6, play a wide role in determination of cell differentiation and control of cell proliferation and movement [1].

WebDec 9, 2024 · α5(IV) collagen is expressed in luminal breast cancer and regulates breast cancer cell proliferation. (A) Heatmap of Pearson's correlation coefficient of BM components (green font: major α1(IV) and α2(IV); red font: minor α5(IV)), breast cancer subtype scores (purple font), and luminal breast cancer key transcription factors ERα and GATA-3 (blue … WebGATA-3 appears to control a set of genes involved in the differentiation and proliferation of breast cancer. The expression of GATA-3 has a strong association with estrogen receptor-alpha expression in breast cancer …

WebIntroduction. As we all know, breast cancer is the most common type of malignant tumor in women, which seriously harms women’s health. 1 It has become the major cause of …

WebApr 19, 2024 · GATA3 is mutated in 12–18% of primary and metastatic estrogen receptor (ER)-positive breast cancers, with predominantly frameshift mutations and mutations affecting splice sites 1,2,3,4.It is ... aterm pa-wg1200hs4WebThe Novel Marker GATA3 is Significantly More Sensitive Than Traditional Markers Mammaglobin and GCDFP15 for Identifying Breast Cancer in Surgical and Cytology … aterm sa3500g カタログWebOct 1, 2024 · The expressions of GCDFP-15 and MGB in ER-negative breast carcinoma were only 15% and 35% [3]. These data revealed the limitations of utility of these biomarkers in the workup of tumors of unknown origin. GATA3 (GATA binding protein 3 to DNA sequence: [A/T]GATA[A/G]) is a member of the zinc-finger transcription factor family. aterm pa-wx3600hpWebNov 20, 2014 · GATA binding protein 3 (GATA3) is a regulator of mammary luminal cell differentiation, and an estrogen receptor (ER) associated marker in breast cancer. Tumor suppressor functions of GATA3 have been demonstrated primarily in basal-like breast cancers. Here, we focused on its function in luminal breast cancer, where GATA3 is … he aloha no honolulu 歌詞WebGATA-3 b regulates luminal epithelial cell differentiation in the mammary gland, is an important regulator of T cell development and plays an important role in endothelial cell biology. GATA-3 is one of the three genes mutated in 10% of breast cancers. Nuclear expression of GATA-3 in breast cancer is considered a marker of luminal cancer in ER+ ... aterm pingテストWebDec 1, 2011 · GATA3 inhibits lysyl oxidase-mediated metastases of human basal triple-negative breast cancer cells. Chu IM et al: 19084267: 2009: The significance of GATA3 expression in breast cancer: a 10-year follow-up study. Ciocca V et al: 19483726: 2009: GATA3 inhibits breast cancer growth and pulmonary breast cancer metastasis. … he aloha no punaluuWebThe point of identification of primary breast cancer from secondary cancer is that the former should be able to find the composition of the catheter in situ or the small leaf in situ on HE section. 21 It is an important hint for the diagnosis of metastasis to the breast if the histological ... GATA-3 or Mammaglobin. In such cases, SOX-10 may ... he antoivat hänelle aseen