WebMay 27, 2024 · PUBLISHED 27 May 2024 Anifrolumab is a first-in-class type I interferon receptor antibody WILMINGTON, Del., May 27, 2024 – The first patients have been dosed in the IRIS Phase III clinical trial of anifrolumab in lupus nephritis (LN). Up to 60% of patients with lupus develop kidney involvement. WebAnifrolumab, sold under the brand name Saphnelo, is a monoclonal antibody used for the treatment of systemic lupus erythematosus (SLE). It binds to the type I interferon receptor, blocking the activity of type I interferons such as interferon-α and interferon-β. [medical citation needed]Anifrolumab was approved for medical use in the United States in July …
FDA Approves New Lupus Drug Anifrolumab (Saphnelo)
WebJan 2, 2024 · Anifrolumab mode of action, pharmacodynamics, and pharmacokinetics. Anifrolumab (previously MEDI-546) is a fully human IgG1κ monoclonal antibody that blocks the action of all type I IFNs by binding to subunit 1 of the type I IFNAR (IFNAR1) with high affinity and specificity . Anifrolumab also induces the internalization of IFNAR1, thereby ... WebOct 18, 2024 · The active substance in Saphnelo, anifrolumab, is a monoclonal antibody (another type of protein) designed to attach to this receptor, thereby preventing type I … s\u0026w 629-3 for sale
Anifrolumab, a monoclonal antibody to the type I …
WebAnifrolumab (anifrolumab-fnia; Saphnelo™) is a monoclonal antibody antagonist of the type 1 interferon receptor (IFNAR). It is being developed by AstraZeneca (under license from Medarex, now Bristol-Myers Squibb) for the treatment of autoimmune disorders, including systemic lupus erythema … Anifrolumab: First Approval Drugs. WebAnifrolumab (anifrolumab-fnia; Saphnelo™) is a monoclonal antibody antagonist of the type 1 interferon receptor (IFNAR). It is being developed by … WebMay 6, 2024 · The trial investigators randomly assigned 147 patients with LN in a 1:1:1 ratio to receive placebo, a basic regime of monthly intravenous 300 mg anifrolumab or an intensified regime with 900 mg ... s\u0026w 627 pro for sale